Nigel Yarlett, PhD
B.Sc(Hons) University College Cardiff, Wales, UK
Ph.D. University College Cardiff, Wales, UK and Hannah Research Inst., Scotland, UK
- Advanced Biochemistry
- Introduction to Chemistry II
- Elements of Chemistry II
My research concerns the investigation of polyamine metabolism by the human parasites, Cryptosporidium parvum, an opportunistic parasite of HIV positive individuals, and Trichomonas vaginalis, a sexually transmitted parasite. The studies are broadly aimed at elucidating the metabolism and function of polyamines by these parasites with an eventual aim of developing new chemotherapeutic strategies to treat the diseases caused by these parasites.
- Purification & properties of key polyamine biosynthetic enzymes from Cryptosporidium parvum and Trichomonas vaginalis
- Continuous culture of C. parvum
- Role of polyamines in C. parvum life cycle
- Development of polyamine analogs as antiparasitic agents
Selected from over 100 publications
- Biochemical characterization of a mitochondrial-like organelle from Blastocystis sp. subtype 7. Lantsman Y, Tan KS, Morada M, Yarlett N. Microbiology. 2008 Sep;154(Pt 9):2757-66.
- Divergent polyamine metabolism in the Apicomplexa. Cook T, Roos D, Morada M, Zhu G, Keithly JS, Feagin JE, Wu G, Yarlett N. Microbiology. 2007 Apr;153(Pt 4):1123-30.
- Cryptosporidium parvum spermidine/spermine N1-acetyltransferase exhibits different characteristics from the host enzyme. Yarlett N, Wu G, Waters WR, Harp JA, Wannemuehler MJ, Morada M, Athanasopoulos D, Martinez MP, Upton SJ, Marton LJ, Frydman BJ. Mol Biochem Parasitol. 2007 Apr;152(2):170-80. Epub 2007 Jan 9.