Inside Haskins Lab: Working to Cure Sleeping Sickness

  Haskins Laboratories
   

Haskins Laboratories

The Haskins Laboratories, which have been at Pace since 1970, have been centered on researching possible cures for diseases that are out of the public spotlight. “We work on things that aren’t stylish—not in vogue. And consequentially, things that aren’t typically funded to a great extent,” says Nigel Yarlett, PhD, director of the Haskins Laboratories at Pace University.

Recently, parasitologists at the Lab have focused their attention on new methods of treatment for Human African Trypanosomiasis (HAT), also known as sleeping sickness. Researchers are working to develop compounds that will help treat sleeping sickness in the nearly half-a-million infected inhabitants of sub-Saharan Africa. “Some drugs were developed in the 1920s to treat the illnesses, but these drugs had an arsenic base,” Dr. Yarlett says. “For those being treated with these drugs, death occurred more quickly than it would have if they hadn’t been treated!…These are the first new drugs [developed to treat HAT] in 30 years. We’re very excited.”

The researchers have discovered a new line of compounds that have been effective in curing mice and are now being tested on larger mammals. They will be going into clinical trials with a cohort of 1,000 human patients in Africa later this year. They plan to target villages in Africa, whose inhabitants are cut off from any sort of medical access. “For the people living in these villages, this sort of sickness is just a way of life,” says Dr. Yarlett.

Additionally, workers at the Haskins Laboratories are attempting to develop a first line of treatment for a far more global issue—cryptosporidiosis, a waterborne illness that causes chronic diarrhea. Its major impact has been among those with weakened immune systems, including those who are HIV+, receiving cancer treatments, or those that have undergone organ transplantation. “Cryptosporidosis is one of the major causes of death in HIV+ people and currently there is nothing available to treat it,” Dr. Yarlett says. However Dr. Yarlett hopes that the great minds at Pace will soon be able to help on that front as well.

“In the world of parasitology, the Haskins Lab is recognized worldwide,” says Dr. Yarlett. “It’s one of the reasons I came to Pace, and I’m proud to be a part of such a great asset to the University.”

The Haskins Laboratories was founded in 1935 at General Electrical and Union College by four young and innovative scientists, one of whom became its namesake, Caryl Haskins, a physicist and geneticist. In 1970 it split into two divisions, the Microbiology Division, under Seymour Hutner (one of the original scientists) affiliated with Pace University, and the Speech Recognition and Cognition Division affiliated with Yale University. The Pace institute is funded by a number of sources, including  the National Institutes of Health (in collaboration with the University of Texas Southwestern Medical Center in Dallas), Drugs for Neglected Diseases initiative (DNDi), and Genzyme Corp and works  in collaboration with pharmaceutical companies Scynexis and Anacor.